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[Expression of EBI3 and p28 mRNA in the brain and spinal cord of chronic model of experimental autoimmune encephalomyelitis in C57BL/6J mice].
Yan JJ, Wang R, Wang YZ, Zhou WB. Yan JJ, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008 Nov;33(11):1028-36. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008. PMID: 19060371 Chinese.
OBJECTIVE: To investigate the expression of EBI3 and p28 mRNA (the 2 subunits of IL-27) in the brain and spinal cord of the model of experimental autoimmune encephalomyelitis (EAE), and to explore their effect on EAE. ...Additionally, there was no remarkable differe …
OBJECTIVE: To investigate the expression of EBI3 and p28 mRNA (the 2 subunits of IL-27) in the brain and spinal cord of the mo …
Single-cell atlas of splenocytes reveals a critical role of a novel plasma cell‒specific marker Hspa13 in antibody class-switching recombination and somatic hypermutation.
Zhai B, Liu X, Xu Y, Zhu G, Zhou S, He Y, Wang X, Su W, Han G, Wang R. Zhai B, et al. Mol Immunol. 2022 Jan;141:79-86. doi: 10.1016/j.molimm.2021.11.014. Epub 2021 Nov 24. Mol Immunol. 2022. PMID: 34837777
In terms of its function, we found that the CD19(cre)-mediated conditional knock-out (cKO) of Hspa13 reduced the expression of Ebi3 and IL-10 in PCs. Ebi3 and IL-10 are important factors in IL-4-secreting type 2 helper T cell (Th2) activation and differentiation. .. …
In terms of its function, we found that the CD19(cre)-mediated conditional knock-out (cKO) of Hspa13 reduced the expression of Ebi3 a …
Production of IL-27 in multiple sclerosis lesions by astrocytes and myeloid cells: Modulation of local immune responses.
Sénécal V, Deblois G, Beauseigle D, Schneider R, Brandenburg J, Newcombe J, Moore CS, Prat A, Antel J, Arbour N. Sénécal V, et al. Glia. 2016 Apr;64(4):553-69. doi: 10.1002/glia.22948. Epub 2015 Dec 9. Glia. 2016. PMID: 26649511
IL-27 contribution to local modulation of immune responses in the brain of MS patients was investigated. The expression of IL-27 subunits (EBI3 and p28) and its cognate receptor IL-27R (the gp130 and TCCR chains) was elevated within post-mortem MS brain lesio …
IL-27 contribution to local modulation of immune responses in the brain of MS patients was investigated. The expression of IL-27 subu …
Vitamin D Modulates the Expression of IL-27 and IL-33 in the Central Nervous System in Experimental Autoimmune Encephalomyelitis (EAE).
Mohammadi-Kordkhayli M, Ahangar-Parvin R, Azizi SV, Nemati M, Shamsizadeh A, Khaksari M, Moazzeni SM, Jafarzadeh A. Mohammadi-Kordkhayli M, et al. Iran J Immunol. 2015 Mar;12(1):35-49. Iran J Immunol. 2015. PMID: 25784096 Free article.
At day 31, the mice were scarified and their spinal cords and brains were harvested. The expression of the IL-27 and IL-33 mRNA in the spinal cord was measured using real time-PCR. ...In both PBS- and olive oil-treated EAE groups, the expression of IL-27 EBI3 mRNA w …
At day 31, the mice were scarified and their spinal cords and brains were harvested. The expression of the IL-27 and IL-33 mRNA in th …
Soluble serum VCAM-1, whole blood mRNA expression and treatment response in natalizumab-treated multiple sclerosis.
Petersen ER, Søndergaard HB, Oturai AB, Jensen P, Sorensen PS, Sellebjerg F, Börnsen L. Petersen ER, et al. Mult Scler Relat Disord. 2016 Nov;10:66-72. doi: 10.1016/j.msard.2016.09.001. Epub 2016 Sep 6. Mult Scler Relat Disord. 2016. PMID: 27919501
Natalizumab binds to the very late antigen-4 and inhibits vascular cell adhesion molecule-1 (VCAM-1)-mediated transmigration of immune cells across the blood-brain-barrier. This is associated with decreased serum concentrations of soluble (s)VCAM-1 and an altered compositi …
Natalizumab binds to the very late antigen-4 and inhibits vascular cell adhesion molecule-1 (VCAM-1)-mediated transmigration of immune cells …
Increased interleukin-27 cytokine expression in the central nervous system of multiple sclerosis patients.
Lalive PH, Kreutzfeldt M, Devergne O, Metz I, Bruck W, Merkler D, Pot C. Lalive PH, et al. J Neuroinflammation. 2017 Jul 24;14(1):144. doi: 10.1186/s12974-017-0919-1. J Neuroinflammation. 2017. PMID: 28738904 Free PMC article.
We further confirmed by immunohistology of patient biopsies the identity of IL-27 producing cells in the brain of active MS lesions. RESULTS: We observed that IL-27 levels are increased in the CSF but not in the sera of RRMS compared to HD. ...
We further confirmed by immunohistology of patient biopsies the identity of IL-27 producing cells in the brain of active MS lesions. …